137
2019
Study Title
HMGB1, sCD62P, sCD40L and platelet transfusion
Study Description
Hypothesis:
Recent evidence has highlighted a central role for platelets in the host inflammatory and immune responses. The involvement of platelet components (PC) in serious adverse reactions (SAR)—particularly on a critically ill patient’s context—could be related, at least in part, to the inflammatory functions of platelets, acquired during storage lesions. In SARs-associated PCs, supernatant fractions contained higher levels of sCD40L or HMGB1 than the control component.
Aims/objectives:
Now it is necessary to test different parameters related to the process and storage of preparation of platelets (A single donor apheresis, Whole blood (WB)-derived PC, Cold platelets or Frozen platelets, various PAS, Cells separators, PRT, ect ...)
Recent evidence has highlighted a central role for platelets in the host inflammatory and immune responses. The involvement of platelet components (PC) in serious adverse reactions (SAR)—particularly on a critically ill patient’s context—could be related, at least in part, to the inflammatory functions of platelets, acquired during storage lesions. In SARs-associated PCs, supernatant fractions contained higher levels of sCD40L or HMGB1 than the control component.
Aims/objectives:
Now it is necessary to test different parameters related to the process and storage of preparation of platelets (A single donor apheresis, Whole blood (WB)-derived PC, Cold platelets or Frozen platelets, various PAS, Cells separators, PRT, ect ...)
Study Status
Completed
Publication Number
158
Teams
CC
Study Leaders
Cognasse