Classifying Platelet Transfusion Refractoriness–
HLA Specificities, HLA Types and Patient Factors

Platelet transfusion refractoriness is a common clinical finding in transfused patients who have oncologic and hematologic diagnoses. Patients with immune-based refractoriness are usually supported with HLA-matched/compatible units and/or crossmatched units. Little is known about the HLA specificities that cause platelet refractoriness. Are there some antibody specificities that are more commonly identified in refractory patients?

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Cohn, Delaney, Jacquot, Fitzpatrick